It was Dr Bradstreet who first tested for nagalase in autism after reading Dr Yamamoto's paper on HIV/AIDS. Dr Yamamoto used nagalase as a blood marker to record levels of this enzyme throughout a course of 100ng weekly intramuscular injections. Incredibly all 30 test subjects had their nagalase levels normalised after only a few months of treatment. Dr Yamamoto considered these results a success and declared all 30 recovered and follow up tests showed no rise in nagalase levels.

Dr Bradstreet also used the nagalase blood test in his paper, along with the cgi scale, to measure the success of gcmaf in autism. In 85% of cases gcmaf was able to reduce nagalse levels with some falling into the range considered normal. I am not aware of any follow up tests 2 years after publishing his initial results.

So what is nagalase?

Nagalase is produced in small amounts in our intestines and serves to break down mucin glycoproteins in our food. Normal nagalase levels range between 0.38 & 0.63 nmole/min/mg protein.

However this enzyme has been hijacked by pathogens and cancers with the sole purpose of collapsing the immune system by sabotaging the Vitamin D molecule. It literally cuts the 3 sugars from Vitamin D that are required for immune activation. Because it is an enzyme nagalase repeats this action time and time again without causing any collateral damage whatsoever.

Until Dr Yamamoto outed nagalase we had no idea as to how cancers and viruses were able to collapse the immune system and grown unchecked.

Without doubt nagalase is an extremely useful marker for cancer and could be used more widely in place of some of the extremely invasive, not to mention dangerous and potentially deadly tests currently employed in the cancer industry. Any rise in nagalase levels could indicate that cancer is growing somewhere in the body. However it does not show where the cancer is growing so the current treatments would not be of much use. The oncologist would be clueless as to where to begin treatment because this marker is so sensitive and indicates cancer cell proliferation before anything shows up on standard tests.

The most sensible course of action would be to stimulate the immue system and let our own natural killer cells take care of the problem.

Nagalase is also a useful test to show how successful any cancer treatment is as levels of this enzyme are directly proportional to the tumour burden...reduce the tumour and nagalase levels drop.

Nagalase is secreted by all cancer cells, viruses, bacteria and most likely other pathogens in an attempt to collapse the immune system. Where as cancer cells will multiply at a fairly constant rate, pathogens are able to divide and multiply rapidly. During this phase we would expect to see nagalase levels rise significantly.

Lets assume the level of pathogen multiplication and nagalase secrection was able to compromise the immune system what would happen then? As with most actions in the body, to conserve energy we would expect to see nagalase levels drop as the threat from the immune system is no longer a serious one.

So a pathogethen induced compromised immune system could, in all theory, show low levels of nagalase and not high as in the case of cancers.

Stimulate the immune system by waking up the immune cells to attack the pathogens would in return see nagalase levels rising again as the pathogens once again try to sabotage the vitamin d molecules that are activating our immune cells.

A few years ago we tested nagalase levels in ME, threw in a few healthy controls and the latter came back with higher nagalase than the 'sick' ME group.

I am writing this on a plane and, as always, can feel my nose and throat itching as my first line of immune defence is trying to ward off all the pathogens shared on this plane by the air conditioning. A nagalase blood test now would most likey show it has risen since arriving at the airport a few hours ago.

So nagalase levels will rise and fall throughout the day depending on what pathogen is trying to take up resident in the host. High nagalase levels resulting from pathogens is not necessarily indicative of a compromised immune system, as in the case of cancers, but instead is reflecive of the constant battle taking place at a microscopic level in each and every one of us.

So please draw your own conclusions but in my own personal experience all autistic children tested for nagalase have elevated levels of this enzyme. Any reduction in these levels could be an indication of successful treatment but any rise in these figures is what can be expected within any person who has a healthy immune system that is threatened by any pathogen.

As autism appears to involve many co-infections specific blood tests tailored to that particular child would be more useful than nagalase. And as our immune cells require Vitamin D for activation then a blood test to measure these levels is far more relevant if you decide to choose gcmaf/mafactive as an intervention for your child.

I hope you have found this helpful and please do leaving any questions or comments you may have below.

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